基因敲除鼠的特点有哪些？可发挥哪些作用？

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　　在动物模型中，基因敲除小鼠主要分为两类，即完全基因敲除小鼠和条件性基因敲除小鼠，两者分别应用于更为尖端的生物医学研究领域。那么，基因敲除鼠的特点有哪些？可发挥哪些作用？下面就让小编来为大家简单介绍一下：

　　1、完全基因敲除小鼠。完全基因敲除小鼠（Knockout, KO）是通过基因敲除技术，将靶基因的所有外显子或重要外显子、功能区域敲除，导致该基因在所有组织细胞中均不表达。这种基因敲除鼠模型构建周期较短，交配流程简单，适用于研究目的基因对全身生理或病理的功能。然而，大约有1/3的基因纯合敲除后会导致小鼠胚胎期死亡或出生期死亡，且可能引发其他基因的代偿，导致基因敲除后没有明显表型改变。

　　2、条件性基因敲除小鼠。条件性基因敲除小鼠（Conditional Knockout, CKO）通过染色体位点特异性重组酶系统（如Cre-LoxP）实现基因在特定组织或细胞中的敲除，而在其他组织或细胞中表达正常。这种基因敲除鼠模型可以避免基因胚胎致死的问题，并且能够实现基因在特定时间或组织的表达，是研究靶基因功能的重要工具。这种小鼠的交配流程较为复杂，构建周期较长，但其多功能性使其能够与不同工具鼠灵活搭配使用，系统地研究目的基因在不同组织器官发生、发育或疾病发生、治疗过程中的作用与机制。

　　关于基因敲除鼠的特点及作用，小编就先为大家介绍到这里。客户可以根据研究需求选择合适的产品，集萃药康可为客户提供多种小鼠模型，以确保研究项目能够顺利进行。更多产品信息，可通过集萃药康的官网来进一步咨询了解。‌‌

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